Cubipol Glycerol

The proprietary Cubipol backbone, developed in-house by Cube Biotech, condenses the positive effects of previously available backbones like SMA, DIBMA, and UltrasoluteTM Amphipol. This new development delivers a new multimodal copolymer backbone, making the Cubipol series the first commercially available next-generation copolymer with 9 available off-the-shelf modified variants.

It joins the Next Generation Copolymers AASTY and Ultrasolute™ Amphipol, making solubilization and stabilization of membrane proteins a simpler and more effective endeavor than ever before.

This modification of the Cubipol backbone makes it one of the derivates with less charge like Sulfo-Cubipol and Glyco-Cubipol. The low charge makes it, so the copolymer does not interfere with charge-sensitive membrane protein processes like protein-protein and protein-lipid interactions.

Features

State: Lyophilized Powder, to be solved with water

Full Name: Cubipol Glycerol

Buffer: HEPES

pH after solving: 7.5

pH Stability of Copolymer: 6.0-10

Absorbance at 280nm: No

Molecular Weight: 10.7 kDA

Ca2+ tolerance: 10 mM

Mg2+ tolerance: 20 mM

Solubility: > 10% (H2O)

Polymerization Type: Free-Radical

Shipping Temperature: Ambient Temperature

Storage of lyophilized copolymer: -20°C for several years

Storage of dissolved copolymer: 2-8°C for several days