Published with this product (4)
2024International Journal of Molecular Sciences, 25(8), 4509
Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier
Mahmoud Elashiry, Angelica Carroll, Jessie Yuan, Yutao Liu, Mark Hamrick, Christopher W. Cutler, Qin Wang, and Ranya Elsayed
doi:10.3390/ijms250845092024Dentistry Review, 4(3), 100114
Periodontitis Gingival Tissue Exosomes Cross and Compromise Human BBB in an In-Vitro 3D Model
Tigerwin Yang and Ranya Elsayed
doi:10.1016/j.dentre.2024.1001142021Neuroscience Letters. doi; 10.1016/j.neulet.2021.136298
Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, and Kwan Hee Lee
doi:10.1016/j.neulet.2021.1362982020United States Patent Application 20200230218
Method of Treating Central Nervous System Disease
Sookhee Bang, Jeong Kuen Song, Seung-wook Shin, Kwan Hee Lee, and Ho June Lee
Description
Human BBB is available only to US customers
Our model mimic transport properties of the Blood Brain Barrier (BBB) due to the formation of tight junctions, higher expression of specific carriers, or great cell viability. We developed a 3D in vitro model of the BBB by culturing brain endothelial cells with pericytes and astrocytes layered in an insert. This model improves endothelial cell polarization and enhances the formation of tight junctions, provide better endothelial cell-to-cell contact that is important for barrier development, and prevent the dilution of secreted neurotrophic factors, and these conditions collectively led to the development of an in vitro model that can truly mimic the BBB.
Models are made to order. Please allow 4-8 weeks for completion.
Models come with media. Additional media can be ordered (catalog # NMBBB01).
BBB model can be used for transport and permeability studies from ions to macromolecules.
Models are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom.
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For research use only. Not for diagnostic or clinical use.