Cubipol Biotin

The proprietary Cubipol backbone, developed in-house by Cube Biotech, condenses the positive effects of previously available backbones like SMA, DIBMA, and UltrasoluteTM Amphipol. This new development delivers a new multimodal copolymer backbone, making the Cubipol series the first commercially available next-generation copolymer with 4 available off-the-shelf modified variants.

It joins the Next Generation Copolymers AASTY and Ultrasolute™ Amphipol, making solubilization and stabilization of membrane proteins a simpler and more effective endeavor than ever before.

This first-of-its-kind, this functionalized version of Cubipol is tagged with biotin, enabling tag-free solubilization and stabilization of your target protein. There is no protein-labeling required, and the accesibility to the ecto- and cytoplasmatic domain is preserved.

This functionalized copolymer is particularly suited for downstream applications that require copolymer stabilization without affecting the protein. These include drug screening, high-throughput processes and assay development.

Features

State: Lyophilized Powder, to be solved with water

Full Name: Cubipol Biotin in 50 mM HEPES, pH 7.5

Buffer: HEPES

pH after solving: 7.5

pH Stability of Copolymer: 5.0-10

Absorbance at 280nm: No

Molecular Weight: 7.4 kDA

Ca2+ tolerance: 40 mM

Mg2+ tolerance: 40 mM

Solubility: > 10% (H2O)

Polymerization Type: Free-radical

Shipping Temperature: Ambient Temparature

Storage of lyophilized copolymer: -20°C for several years

Storage of dissolved copolymer: 2-8°C for several days