Sulfo-Cubipol Biotin

The proprietary Cubipol backbone, developed in-house, condenses the positive effects of previously available backbones like SMA, DIBMA, and UltrasoluteTM Amphipol. This new development delivers a new multimodal copolymer backbone, making the Cubipol series the first commercially available next-generation copolymer with 4 available off-the-shelf modified variants.

It joins the Next Generation Copolymers AASTY and Ultrasolute™ Amphipol, making solubilization and stabilization of membrane proteins a simpler and more effective endeavor than ever before.

The low charged, zwitterionic copolymer variation resembles softer surfactants with a high resistance to extreme pH values, ionic strength and divalent ion concentrations (details in the table below). It belongs to the Cubipol class with low charge, which allows for the uninterrupted study of charge-sensitive interactions between membrane proteins and lipids.

This functionalized copolymer is particularly suited for downstream applications that require copolymer stabilization without affecting the protein. These include drug screening, high-throughput processes and assay development.

Features

State: Lyophilized Powder, to be solved with water

Full Name: Sulfo-Cubipol Biotin in 50 mM HEPES, pH 7.5

Buffer: HEPES

pH after solving: 7.5

pH Stability of Copolymer: 5.0-10

Absorbance at 280nm: No

Molecular Weight: 14 kDA

Ca2+ tolerance: 40 mM

Mg2+ tolerance: 40 mM

Solubility: > 10% (H2O)

Polymerization Type: Free-radical

Shipping Temperature: Ambient Temperature

Storage of lyophilized copolymer: -20°C for several years

Storage of dissolved copolymer: 2-8°C for several days