GPCR Expressing CHO-K1 Cells

CHO-K1 cells, derived from Chinese Hamster Ovary (CHO), are among the most extensively used mammalian cell lines in biotechnology and biomedical research. These cells are prepared to express G protein-coupled receptors (GPCRs) of interest, enabling them to serve as critical platforms for the production, study, and characterization of proteins. GPCRs are an expansive and essential family of integral membrane proteins that play a vital role in various signal transduction pathways and are consequently major targets for therapeutic drug development.

The exact expression parameters are set by the customer, with over 450 options available. To get the cells you need, please provide us with the protein accession number you are looking for. The protein accession number serves as a unique identifier assigned to a specific protein sequence within various biological databases, such as UniProt or GenBank. The lead time for the cells is 6-8 weeks, as they are prepared after ordering.

CHO-K1 cells exhibit a robust growth rate and are adaptable to various culture conditions, including suspension and adherent cultures, making them highly valuable for large-scale bioproduction processes.

Among the notable GPCRs often expressed in CHO-K1 cells are the β2-adrenergic receptor (β2-AR), the adenosine A2A receptor, various chemokine receptors (such as CXCR4), and opioid receptors. These receptors are frequently the focus of studies aimed at elucidating their roles in various disease states and as potential therapeutic targets.

At the end of the datasheet, there is more information on the advantages, applications, challenges, strategies, and assays related to the cells.

Cells are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom.