Human Hepatic Stellate Cells (NASH)

Human Hepatic Stellate Cells (HHSCs) from NASH donors are isolated from human liver tissue with a confirmed histological diagnosis of Non-Alcoholic Steatohepatitis (NASH). These cells are cryopreserved at the earliest passage to preserve their critical in vivo phenotype.

Hepatic Stellate Cells are the principal effector cells in liver fibrosis. In the healthy liver, they reside in a quiescent state, storing Vitamin A. Upon liver injury, as in NASH, they undergo "activation," transforming into proliferative, contractile, and fibrogenic myofibroblasts. HHSCs from a NASH background are pre-activated and provide an unparalleled in vitro model for studying the mechanisms of progressive fibrogenesis, screening anti-fibrotic therapeutics, and investigating the pathogenesis of NASH.

Cells are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom.