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Neuromics
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Primary Antibody · Mouse IgG

Tau

Species
Human, Mouse, Rat
Applications
ICC, WB, IHC, IF

Description

Tau is a low molecular weight member of the microtubule associated protein or MAP family. Several serious human diseases are associated with accumulations of tau protein, most notably the neurofibrillary tangles of Alzheimer's disease. Accumulations of tau in neurons are also characteristic of chronic traumatic encephalopathy, Pick’s disease and several other neurodegenerative diseases. Together these disorders are known as “tauopathies”.
Immunofluorescent analysis of cortical neuron-glial culture from E20 rat stained with mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green, and costained with chicken pAb to GFAP dilution 1:5,000 in red. The blue is DAPI staining of nuclear DNA. MO22191 stains perikarya, dendrites and axons of neurons, while the GFAP antibody labels astrocytes.
Immunofluorescent analysis of cortical neuron-glial culture from E20 rat stained with mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green, and costained with chicken pAb to GFAP dilution 1:5,000 in red. The blue is DAPI staining of nuclear DNA. MO22191 stains perikarya, dendrites and axons of neurons, while the GFAP antibody labels astrocytes.
Western blot analysis of tissue lysates using mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green: [1] protein standard (red), [2] rat brain, [3] rat spinal cord, [4] mouse brain, [5] mouse spinal cord. Tau protein is expressed as up to 9 different isoforms of different molecular weight, and so appears as multiple closely spaced bands in the region of the blot from 48 kDa to 67 kDa with some higher molecular weight “big tau” Isoforms.
Western blot analysis of tissue lysates using mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green: [1] protein standard (red), [2] rat brain, [3] rat spinal cord, [4] mouse brain, [5] mouse spinal cord. Tau protein is expressed as up to 9 different isoforms of different molecular weight, and so appears as multiple closely spaced bands in the region of the blot from 48 kDa to 67 kDa with some higher molecular weight “big tau” Isoforms.

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For research use only. Not for diagnostic or clinical use.