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Neuromics
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Recombinant Protein · Protein

GDNF (Human, Mouse)

Cited in 2 papers
Species
Human, Mouse

Published with this product (2)

Description

GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.  

References:

1. Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. Brain Res Bull 2006 Dec 11;71(1-3):116-26
2. Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y. Gastroenterology 2006 Oct;131(4):1164-78
3. MRI volumetric and intensity analysis of the cerebellum in Parkinson's disease patients infused with glial-derived neurotrophic factor (GDNF).Exp Neurol 2006 Apr;198(2):450-6
4. Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: their possible correlation in astrocytes. Brain Res 2006 Feb 9;1072(1):215-23
5. Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age. Brain Res Bull 2005 Dec 15;68(1-2):31-41
6. Effects of fibroblast growth factor and glial-derived neurotrophic factor on akinesia, F-DOPA uptake and dopamine cells in parkinsonian primates.Parkinsonism Relat Disord 2002 Jun;8(5):311-23.
Immunofluorescence for hN2 Human Neurons Discovery Kit differentiated in the presence of 25 ng/ml GDNF. Cells were also counterstained for nuclei (DAPI) and Tuj 1-Neuron-specific class III beta-tubulin and TH-Tyrosine Hydroxylase.
Immunofluorescence for hN2 Human Neurons Discovery Kit differentiated in the presence of 25 ng/ml GDNF. Cells were also counterstained for nuclei (DAPI) and Tuj 1-Neuron-specific class III beta-tubulin and TH-Tyrosine Hydroxylase.

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For research use only. Not for diagnostic or clinical use.