Published with this product (1)

2024Nature Immunology
Mapping Spatial Organization and Genetic Cell-State Regulators to Target Immune Evasion in Ovarian Cancer
Christine Yiwen Yeh, Karmen Aguirre, Olivia Laveroni, Subin Kim, Aihui Wang, Brooke Liang, Xiaoming Zhang, Lucy M. Han, Raeline Valbuena, Michael C. Bassik, Young-Min Kim, Sylvia K. Plevritis, Michael P. Snyder, Brooke E. Howitt, and Livnat Jerby
doi:10.1038/s41590-024-01943-5

Description

BMP-7 (osteogenic protein 1) belongs to the Bone-growth regulatory factors that are members of the transforming growth factor-beta (TGF-beta) superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

References:

1. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum 2007 Jun;56(6):1880-93
2. Bone morphogenetic protein 7 (BMP7) expression is a potential novel prognostic marker for recurrence in patients with primary melanoma. Cancer Biomark 2007;3(2):111-7
3. Ectopic ossification of the triceps muscle after application of bone morphogenetic protein-7 to the distal humerus for recalcitrant nonunion: a case report. J Hand Surg [Am] 2007 May-Jun;32(5):647-50
4. Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon. Biochem Biophys Res Commun 2007 Jun 1;357(2):467-73
5. Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2007 Feb;48(2):715-26

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