Description
The TNF-related ligand, B cell-activating factor belonging to the TNF family (BAFF), is necessary for normal B cell development and survival, and specifically binds the receptors transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), B cell maturation Ag (BCMA), and BAFF-R.Using specific mAbs, BAFF-R was found to be the predominant BAFF receptor expressed on peripheral B cells, in both humans and mice, and antagonist mAbs to BAFF-R blocked BAFF-mediated costimulation of anti- micro responses. The other BAFF receptors showed a much more restricted expression pattern, suggestive of specialized roles.
BLyS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton.
The BAFF is purified by proprietary chromatographic techniques.
2. TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice. Exp Mol Med 2007 Jun 30;39(3):343-52.
3. BAFF - an essential survival factor for B cells: Links to genesis of ITP and may be of therapeutic target. Med Hypotheses 2007 Jun 23.
4. Elevated serum BAFF levels in patients with autoimmune hepatitis. Hum Immunol 2007 Jul;68(7):586-91.
5. BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice. J Invest Dermatol 2007 Jun 21.
6. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur J Immunol 2007 Jul;37(7):1785-95.
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For research use only. Not for diagnostic or clinical use.