EPO-alpha Human

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.

References:

1. Efficacy and tolerability of intravenous continuous erythropoietin receptor activator: a 19-week, phase II, multicenter, randomized, open-label, dose-finding study with a 12-month extension phase in patients with chronic renal disease.  Clin Ther 2007 Apr;29(4):626-39.
2. The efficacy of preoperative administration of a single dose of recombinant human erythropoietin in pediatric cardiac surgery.  Heart Surg Forum 2007;10(2):E115-9.
3. Neurocognitive dysfunction post-cardiac surgery and the neuroprotective effects of erythropoietin.  Can J Cardiovasc Nurs 2007;17(2):5-8; quiz 8-9, 5.
4. [Pure red cell aplasia in patients treated with recombinant erythropoietin for anemia due to chronic renal disease]  Rinsho Ketsueki 2007 May;48(5):391-6.
5. Erythropoietin, the FDA, and oncology.  N Engl J Med 2007 Jun 14;356(24):2448-51.
6. Do cancer cells express functional erythropoietin receptors?  N Engl J Med 2007 Jun 14;356(24):2447.