Description
ANXA8 is part of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. ANXA8 is an anticoagulant protein that functions as an indirect inhibitor of the thromboplastin-specific complex, which takes part in the blood coagulation cascade. Where co-expressed in the same tissues, ANXA8 is expressed at a 100-fold lower level than Annexin A5. Though, ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells which suggests its involvement in hematopoietic cell differentiation.
ANXA8 Human Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 347 amino acids (1-327 a.a.)and having a total molecular mass of 39 kDa.
ANXA8 is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.
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For research use only. Not for diagnostic or clinical use.