Published with this product (8)

2024American Journal of Physiology-Heart and Circulatory Physiology
Innervation of Adipocytes is Limited in Mouse Perivascular Adipose Tissue
Marie Hanscom, Wilmarie Morales-Soto, Stephanie W Watts, William F. Jackson, and Brian D. Gulbransen
doi:10.1152/ajpheart.00041.2024
2023Nature Communications 14, 5165
Circadian Clock Regulator Bmal1 Gates Axon Regeneration via Tet3 Epigenetics in Mouse Sensory Neurons
Dalia Halawani, Yiqun Wang, Aarthi Ramakrishnan, Molly Estill, Xijing He, Li Shen, Roland H. Friedel, and Hongyan Zou
doi:10.1038/s41467-023-40816-7
2023Research Square
Complex Alterations in Inflammatory Pain and Analgesic Sensitivity in Young and Ageing Female Rats: Involvement of ASIC3 and Nav1.8 in Primary Sensory Neurons
Diego N. Messina, Emanuel D. Peralta, and Cristian G. Acosta
doi:10.21203/rs.3.rs-3433175/v1
2022Scientific Reports, 12:20589
Bone Marrow-Derived Vasculogenesis Leads to Scarless Regeneration in Deep Wounds with Periosteal Defects
Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, and Hideto Kojima
doi:10.1038/s41598-022-24957-1
2019Journal of Neurochemistry
Cutaneous Inflammation Differently Regulates the Expression and Function of Angiotensin II Types 1 and 2 Receptors in Rat Primary Sensory Neurons
Sergio Benitez, Alicia Seltzer, Diego Messina, Mabel Foscolo, Sean Patterson, Christian Acosta
doi:10.1111/jnc.14848

Description

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.

PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016

PGP9.5 staining of rat DRGs (Dilution 1:500)

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