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Neuromics

Primary Antibody · Rabbit IgG

NPY Y2 Receptor

Cited in 17 papers
Species
Mouse, Rat
Applications
WB, IHC, IF

Published with this product (17)

All 17 publications

Description

Neuropeptide Y (NPY) receptors are members of a G protein-coupled receptor superfamily and they mediate a variety of physiological responses including feeding and vasoconstriction. The endogenous ligands of NPY receptors are a family of structurally related peptides, including NPY, peptide YY (PYY), and pancreatic polypeptide (PP). Increased activity of NPY and its receptors, Y1R, Y2R, and Y5R has been found in the brain in many forms of experimental obesity. Furthermore, several association studies have supported the association between NPY2R and obesity.

This NPY Y2 antibody has been extensively characterized in the spinal cord, brain, and distal colon.

Product Highlights:

NPY Y2 receptor immunoreactivity in mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
NPY Y2 receptor immunoreactivity in mouse dorsal root ganglion of wild type (A) and NPY Y2 receptor Knockout (B) animals. Note that unspecific staining is observed in thick, possibly myelinated fibers. Image courtesy of Dr. Tomas Hökfelt, Karolinska Institute.
CCK regulates expression of Y2R in vagal afferent neurons. The Journal of Neuroscience, November 5, 2008, 28(45):11583-11592; doi:10.1523/JNEUROSCI.2493-08.2008
CCK regulates expression of Y2R in vagal afferent neurons. The Journal of Neuroscience, November 5, 2008, 28(45):11583-11592; doi:10.1523/JNEUROSCI.2493-08.2008

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For research use only. Not for diagnostic or clinical use.