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Neuromics

Primary Antibody · Rabbit IgG

mGluR5

Cited in 7 papers
Species
Human, Mouse, Rat
Applications
ICC, WB, IHC

Published with this product (7)

All 7 publications

Description

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.

mGluR5 immunoreactivity in rat globus pallidus. Images courtesy of Dr. Joyce Besheer, UNC.
mGluR5 immunoreactivity in rat globus pallidus. Images courtesy of Dr. Joyce Besheer, UNC.

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For research use only. Not for diagnostic or clinical use.