HSP60 (D307)

Hsp60 is a member of a highly conserved family which includes molecular chaperones. Consistent with their functions as chaperones, Hsp60 and Hsp10 have been suggested to act as docking molecules with a passive role in the maturation of caspase processing, and are primarily known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria . It is now clear that a significant amount of HSP60 is also present in the cytosol of many cells and that it is induced by stress, inflammatory and immune responses, autoantibodies correlated with Alzheimer's, coronary artery diseases, MS, and diabetes.