DEV — test website with test data. Orders here are not real and nothing is shipped or charged.

Tech support 866-350-1500

Pay by PO: enter it at checkout

Neuromics
Log in

Primary Antibody · Rabbit IgG

Caspase-3 (C terminal region)

Species
Human
Applications
ICC, WB, IHC, IF

Description

Caspase 3 is a heterotetramer of two heterodimers arranged in anti-parallel orientation. Caspase 3 activates caspases 6 and 7 and this sequential activation leads to apoptosis. CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Caspase 3 participates in cleavage of Amyloid beta 4A precursor protein which is implicated with neuronal death Alzheimer's disease. Caspase 3 in turn is processed by caspases 8, 9 and 10.
Immunohistochemical detection of Caspase 3 in apoptosis induced Jurkat cells. Cells were fixed with 1% formaldehyde incubated with rabbit polyclonal antibody to C-terminal region of Caspase 3 at 8 μg/mL overnight at 4°C followed by incubation with Donkey anti-rabbit Rhodamine Red conjugated secondary antibodies at 1:200 dilution. Nuclei were counterstained with DAPI (blue).
Immunohistochemical detection of Caspase 3 in apoptosis induced Jurkat cells. Cells were fixed with 1% formaldehyde incubated with rabbit polyclonal antibody to C-terminal region of Caspase 3 at 8 μg/mL overnight at 4°C followed by incubation with Donkey anti-rabbit Rhodamine Red conjugated secondary antibodies at 1:200 dilution. Nuclei were counterstained with DAPI (blue).
Western blot analysis using RA21011
Western blot analysis using RA21011

Related products

For research use only. Not for diagnostic or clinical use.