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Neuromics
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Primary Antibody · Rabbit IgG

PGP9.5/UCHL1

Species
Human, Mouse, Rat, Primate, Bovine
Applications
WB, IF

Description

PGP9.5, Park5 or UCHL1 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. It is an excellent marker for neurons of the CNS and PNS.

The great abundance of this protein in neurons means that it is released from neurons in large amounts following injury or degeneration and is detected in CSF and other bodily fluids. It is used as a bio-marker for Parkinson's Disease (PD), Alzheimer's Disease (AD), Axonal dystrophies and Traumatic Brain Injury (TBI).
Mixed rat neuron/glial cultures stained with PGP9.5/UCHL1 (green). Blue is a DNA stain. Note that the UCHL1 stains neurons strongly and specifically, and that the staining is concentrated in the cell bodies, though some does extend into the dendrites also. Surrounding glial cells are not stained with this antibody, though many are present as visualized using the DNA stain. Inset: Blot of whole bovine brain extract stained with PGP9.5/UCHL1 showing a strong and clean band at about 24kDa.
Mixed rat neuron/glial cultures stained with PGP9.5/UCHL1 (green). Blue is a DNA stain. Note that the UCHL1 stains neurons strongly and specifically, and that the staining is concentrated in the cell bodies, though some does extend into the dendrites also. Surrounding glial cells are not stained with this antibody, though many are present as visualized using the DNA stain. Inset: Blot of whole bovine brain extract stained with PGP9.5/UCHL1 showing a strong and clean band at about 24kDa.

For research use only. Not for diagnostic or clinical use.