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Neuromics
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Primary Antibody · Rabbit IgG

MeCP2 (Methyl-CpG Binding Protein 2)

Species
Human, Mouse, Rat
Applications
ICC, WB, IHC, IF

Description

Methyl-CpG Binding Protein 2 (MeCP2) is a nuclear protein that is found to bind to symmetrical methylated CpG dinucleotide sequences. It is a transcriptional modulator that can alter gene expression epigenetically via binding to methylated DNA. It is involved not only in transcriptional silencing, but also in transcriptional activation, chromatin remodeling, and RNA splicing.  Mecp2is a X-chromosome-linked gene, highly expressed in neurons.
Mouse brain section, which was cut at 45μm on a vibratome after perfusion with 4% paraformaldehyde and overnight fixation, was stained with polyclonal antibody: RA22123. MeCP2 was mainly associated with methylated DNA in nucleus of neuron cells (green). Blue shows DAPI staining of nuclear DNA.
Mouse brain section, which was cut at 45μm on a vibratome after perfusion with 4% paraformaldehyde and overnight fixation, was stained with polyclonal antibody: RA22123. MeCP2 was mainly associated with methylated DNA in nucleus of neuron cells (green). Blue shows DAPI staining of nuclear DNA.

For research use only. Not for diagnostic or clinical use.