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Neuromics
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Primary Antibody · Rabbit IgG

Factor Inhibiting HIF-1/FIH

Species
Mouse, Rat
Applications
ICC, WB, IHC

Description

Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.
Factor Inhibiting HIF1 staining of rat brain tissue (dilution: 1:100).
Factor Inhibiting HIF1 staining of rat brain tissue (dilution: 1:100).
Detection of Factor Inhibiting HIF-1 by Western Blot.
Detection of Factor Inhibiting HIF-1 by Western Blot.

For research use only. Not for diagnostic or clinical use.