Published with this product (1)
2019PNAS
Developmental Plasticity of Epithelial Stem Cells in Tooth and Taste Bud Removal
Ryan F. Bloomquist, Teresa E. Fowler, Zhengwen An, Tian Y. Yu, Kawther Abdilleh, Gareth J. Fraser, Paul T. Sharpe, and J. Todd Streelman
doi:10.1073/pnas.1821202116
Description
Bmi1 induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.
In addition, Bmi1 expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.
Related products
- α-Internexin/NF 66
- alpha Synuclein
- Artemin
- CSF1 (Colony Stimulating Factor 1)
- FGF-2
- GAP43
- GAP43 (IgG)
- MAP2
- MAP2 (Microtubule assoc. protein 2)
- MAP2 (Microtubule Associated Protein 2)
- MARCKS (Myristoylated Alanine Rich C Kinase Substrate)
- Netrin-4 (NTN4)
For research use only. Not for diagnostic or clinical use.