p11 (Calpactin I Light Chain / Annexin II)

The p11 protein belongs to a family of small dimeric proteins which share sequence homologies with S100a and S100b. It is closely related to serotonin transmission in the brain -- and may play a key role in determining suseptability to depression.

In addition, the p11 could be involved in regulating pain via the Nav1.8 pathway.Changes in the extracellularexpression of the plasminogen receptor protein, p11, dramaticallyaffect tumor cell-mediated pericellular proteolysis