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Neuromics
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Primary Antibody · Mouse IgG

Peripherin

Species
Mouse, Rat, Cat, Porcine
Applications
ICC, WB, IF

Description

Peripherin is a type III intermediate filament found initially in sensory neurons of the peripheral nervous system (PNS).  It serves as a marker for autonomic and sensory neurons in the PNS and motor neurons in the CNS. Peripherin is a diagnostic marker in amyotrophic lateral sclerosis and certain neuronally-derived tumors. Brain injuries can also trigger expression of peripherin and the formation of peripherin accumulations in neurons that are normally silent for this gene.  

Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas.  Autoantibodies to peripherin are also frequently seen in the sera of patients with diabetes.

*this antibody has been previously provided as a tissue Culture Supernatant
Mixed neuron/glia cultures from newborn rat brain stained with antibody to peripherin (G) and rabbit polyclonal antibody NF-L (R). A class of large neurons, including those in this image, contain peripherin, while the majority of neurons and their processes contain NF-L and not peripherin. Periperin positive cells often contain a cytoplasmic inclusion next to the nucleus which stains for both peripherin and NF-L, and appear golden in this image. The blue channel reveals the localization of DNA.
Mixed neuron/glia cultures from newborn rat brain stained with antibody to peripherin (G) and rabbit polyclonal antibody NF-L (R). A class of large neurons, including those in this image, contain peripherin, while the majority of neurons and their processes contain NF-L and not peripherin. Periperin positive cells often contain a cytoplasmic inclusion next to the nucleus which stains for both peripherin and NF-L, and appear golden in this image. The blue channel reveals the localization of DNA.

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For research use only. Not for diagnostic or clinical use.