Description

SHIP1 (SH2-containing inositol phosphatase) is a member of the inositol polyphosphate-5- phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta . SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes.

Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome.

Confocal immunofluorescent analysis of HeLa cells labeled with SHIP2 Antibody (left, green) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).

Flow cytometric analysis of HeLa cells, using SHIP2 antibody (blue) compared to a nonspecific negative control antibody (red).

Western blot analysis of total cell lysates from SKMEL5 and HeLa cells, using SHIP2 Antibody.

Description

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