Name: PTEN-induced kinase/PINK1
Brand: Neuromics
SKU: RA19013
Price: 275.00 USD

Published with this product (2)

2011Free Radical Biology and Medicine, Volume 50, Issue 3, Pages 469-476
Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
Micha M.M. Wilhelmus, Susanne M.A. van der Pol, Quentin Jansen, Maarten E. Witte, Paul van der Valk, Annemieke J.M. Rozemuller, Benjamin Drukarch, Helga E. de Vries and Jack Van Horssen
doi:10.1016/j.freeradbiomed.2010.11.033
2010Hum
Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity
Alberto Ferri, Paolo Fiorenzo, Monica Nencini, Mauro Cozzolino, Maria Grazia Pesaresi, Cristiana Valle, Sara Sepe, Sandra Moreno, and Maria Teresa Carrì
doi:10.1093/hmg/ddq383

Description

Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.

n active lesions PINK1 immunostaining was intense in reactive astrocytes (arrows). Double labeling of PINK1 (green) with the astrocytic marker GFAP (red) demonstrated PINK1 expression in astrocytes (inset).

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For research use only. Not for diagnostic or clinical use.