Published with this product (5)
2011Cell, Volume 147, Issue 2, Pages 261-262
Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
Xian-Yu Liu, Zhong-Chun Liu, Yan-Gang Sun, Michael Ross1, Seungil Kim, Feng-Fang Tsai, Qi-Fang Li, Joseph Jeffry, Ji-Young Kim, Horace H. Loh, Zhou-Feng Chen
doi:10.1016/j.cell.2011.08.0432011Neuropsychopharmacology
The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control
María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Ana Vicente-Sánchez, Esther Berrocoso and Javier Garzón. María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Ana Vicente-Sánchez, Esther Berrocoso and Javier Garzón
doi:10.1038/npp.2011.1552007Journal of Neurophysiology
D. Blivis, G. Z. Mentis, M. J. O'Donovan and A. Lev-Tov
doi:10.1152/jn.01313.20062006JBC Papers
MU AND KAPPA OPIOIDS INDUCE THE DIFFERENTIATION OF EMBRYONIC STEM CELLS TO NEURAL PROGENITORS
Eunhae Kim, Amy L. Clark , Alexi Kiss, Jason W. Hahn, Robin Wesselschmidt
doi:10.1074/jbc.M6038622002006MOLECULAR PHARMACOLOGY
C. E. Groer, K. Tidgewell, R. A. Moyer, W. W. Harding, R. B. Rothman, T. E. Prisinzano, and L. M. Bohn
doi:10.1124/mol.106.028258
Description
Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. Several C-terminal splice variants have been identified for the Mu Opioid Receptor (MOR1) including MOR1C. These splice variants appear to differ in their pharmacological selectivity as well as their membrane trafficking.
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