A83-01

Potent and selective ALK4, 5 and 7 inhibitor [1,2]. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency [3]. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts [4]. Cell permeable. Active in vivo. 

References:

1) J Vogt  et al. Cell Signal. 2011 23:1831

2) M Tojo et al. Cancer Sci. 2012 96:791

3) W Li  et al. Cell Stem Cell 2009 4:16

4) X Yuan et al. Stem Cells 2011 29:549