Amlexanox

Improves obesity-related metabolic dysfunction in mouse models [1]. Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 M) [2]. Clinically useful in the treatment of aphthus ulcers [3]. Inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling [4].

References:

1) L Koch Nat. Rev. Endocrinol. 2013 9:185

2) SM Reilly et al. Nat. Med. 2012 19:313

3) SA Nasry et al. J. Clin. Exp. Dent. 2016 8:e517

4) C Cheng et al. Theranostics 2018 8:4633