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Neuromics

Small Compound/Modulator · Modulator

2-NBD-Glucose

Description

Fluorescent glucose uptake probe. May be used to monitor glucose uptake in live cells and as a cell viability indicator [1,2].  Has been used to measure glucose uptake in cultured hippocampal astrocytes using confocal epifluorescence microscopy [3]. NBD fluorescence typically displays excitation/emission maxima of 465/540 nm.  Cell permeable. 

References:

1) Yoshioka et al. (1996), A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli;  Biochim. Biophys. Acta, 1289 5

2) Yamada et al. (2000), Measurement of glucose uptake and intracellular calcium concentration in single, living, pancreatic beta-cells;  J. Biol. Chem., 275 22278

3) Loaiza et al. (2003), Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy;  J. Neurosci., 23 7337

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For research use only. Not for diagnostic or clinical use.