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Neuromics
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Primary Antibody · Rabbit IgG

TRPA1

Cited in 3 papers
Species
Human, Rat
Applications
IHC

Published with this product (3)

Description

Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.

Product Highlights:
TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.
TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.
Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.
Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.

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For research use only. Not for diagnostic or clinical use.