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Neuromics
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Primary Antibody · Rabbit IgG

TRPM2

Species
Mouse, Rat
Applications
WB, IHC

Description

TRPM2 is a member of the melastatin-related TRPM subfamily belonging to the transient receptor potential or TRP channel superfamily. TRPM2 can form a Ca2+-permeable cationic channel activated by intracellular ADP-ribose. The physiological functions of TRPM2 remain largely unknown except that activation of TRPM2 channel can initiate yet unidentified signalling cascades that lead to membrane disruption and eventually cell death.
TRPM2 (red) and GFAP (green) staining of rat hippocampus. Nclei staining is blue. Image courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand.
TRPM2 (red) and GFAP (green) staining of rat hippocampus. Nclei staining is blue. Image courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand.
Detection of TRPM2. Lane 1: CHO cells untransfected. Lane 2: CHO cell transfected with rat TRPM2 Lane 3: Mouse cortical neurons (cultured). Photo courtesy of Dr. Paco Herson, Oregon Health & Science University.
Detection of TRPM2. Lane 1: CHO cells untransfected. Lane 2: CHO cell transfected with rat TRPM2 Lane 3: Mouse cortical neurons (cultured). Photo courtesy of Dr. Paco Herson, Oregon Health & Science University.

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For research use only. Not for diagnostic or clinical use.