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Neuromics

Primary Antibody · Chicken IgY

GFAP

Cited in 19 papers
Species
Human, Mouse, Rat, Primate
Applications
ICC, WB, IHC

Published with this product (19)

All 19 publications

Description

Glial fibrillary acidic protein (GFAP) is the 10nm or intermediate filament protein found specifically in astrocytic cells in the central nervous system.

GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells.

GFAP (red) staining of astrocytes in primary culture (DAPI, blue).
GFAP (red) staining of astrocytes in primary culture (DAPI, blue).
Western blot of whole rat cerebellum homogenate stained with GFAP, at dilution of 1:100,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~50kDa corresponds to rodent GFAP. A lower band at ~45kDa is derived from the GFAP molecule.
Western blot of whole rat cerebellum homogenate stained with GFAP, at dilution of 1:100,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~50kDa corresponds to rodent GFAP. A lower band at ~45kDa is derived from the GFAP molecule.

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For research use only. Not for diagnostic or clinical use.