SAHA (Vorinostat)

Potent and selective histone deacetylase inhibitor [1]. Induces apoptosis in a variety of tumor cell lines (IC50 =  3-8 µM) [2]. Synergizes with kinase inhibitors to kill CNS tumor cells [3]. Prevents diabetes in a mouse model by immunoregulation and β-cell protection [4]. Induces neuronal differentiation in DKFZ-EP1NS cells, a cell line which displays stem cell features such as self-renewal capacity [5]. Neurotrophic activity [6]. Cell permeable.

References:

1) JA Vrana et al. Oncogene 1999 18:7016

2) LM Butler et al. Proc. Natl. Acad. Sci. USA 2002 99:11700

3) Y Tang et al. Cancer Biol. Ther. 2012 13:567

4) DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014 111:1055

5) T Milde et al. Acta. Neuropathol. 2011 122:637

6) S Shukla et al. Mol. Cell. Neurosci. 2016 77:11