IWP-2

IWP-2 is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=27nM) by inhibition of the O-acyltransferase Porcn [1]. Induces cardiomyocyte differentiation from human pluripotent stem cells [2]. An important tool to probe the involvement of the Wnt pathway in physiological processes [3,4]. Cell permeable.

References:

1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer;  Nature Chem. Biol., 5 100

2) Lian et al. (2012), Robust Cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling;  Proc. Natl. Acad. Sci. USA, 109 1848

3) ten Berge et al. (2011), Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells;  Nature Cell. Biol., 13 1070

4) Uyama et al. (2013), Wasf2: a novel target of intermittent parathyroid hormonr administration; Int. J. Mol. Med., 31 1243