Taxol

Induces tubulin polymerization and forms extremely stable and nonfunctional microtubules [1,2]. Induces apoptosis in a variety of cell lines [3]. Clinically useful antitumor agent [4]. Cell permeable. Active in cellular and animal models.

References:

1) EK Rowinsky et al. J. Natl. Cancer Inst. 1990 82:1247

2) S Rao et al. J. Biol. Chem. 1999 274:37990

3) TH Wang et al. Cancer 2000 88:2619

4) TM Mekhail and M Markman Expert Opin. Pharmacother. 2002 3:755