PD-325901

A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM) [1]. Inhibits growth and/or proliferation of a variety of cancer cells [2]. Enhances self-renewal of embryonic stem cells [3]. In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells [4]. In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells [5].

References:

1) SD Barrett et al. Bioorg. Med. Chem. Lett.  2008 18:6501

2) L Ciuffreda et al. Neoplasia 2009 11:720

3) Z Ai et al. Stem Cells Int. 2016 2016:1792573

4) C Li et al. Oncotarget 2016 7:39730

5) W Li et al. Cell Stem Cell 2009 4:16