SP-600125

Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50’s range from 40-90 nM).  >300-fold selectivity for JNK as compared to related MAP kinases [1]. Antiinflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain [2]. Cell permeable and active in vivo.

References:

1) Bennett et al. (2001), SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase; Proc. Natl. Acad. Sci. USA.,  98 13681

2) Rahman  et al. (2012), Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis; Brain Res. 1448 117