Description
Inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 µM) and subsequently inhibits HSP90 client proteins [1]. Induces apoptosis in various cell types [2]. Cell permeable.
References:
1) Neckers et al., (1999), Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity; Invest. New Drugs 17 361
2) Zang et al., (2006), HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis; Mol. Cell. Biochem. 281 111
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For research use only. Not for diagnostic or clinical use.