Nutlin-3

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53 [1]. Displays antiproliferative activity and induces apoptosis in a variety of tumor cells [2-4].

References:

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2..; Science, 303 844.

2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neuroscie. Lett., 513 106

3) Manfe et al. (2012), MDM2 inhibitor nutlin-31 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487

4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859