Prostaglandin E2

Prostaglandin E2 (PGE2) is an endogenous prostaglandin derived from the action of cyclooxygenase on arachidonic acid.  PGE2 has diverse biological actions in the areas of inflammation, cancer, immune modulation, fertility, smooth muscle relaxation and hematopoietic stem cell homeostasis. PGE2 acts through four distinct receptors: EP1, EP2, EP3, EP4.

References:

1) Healy (1990) Progesterone receptor antagonist and prostaglandins in human fertility regulation: a clinical review Reprod.Fertil.Dev. 2 477

2) Greenhough et al. (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment Carcinogenesis 30 377

3) Kalinski (2012) Regulation of Immune Responses by Prostaglandin E2 J.Immunol. 188 21

4) North et al. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447 1007

5) Hoggatt et al. (2013) Differential stem- and progenitor-cell trafficking by prostaglandin E2 Nature 495 365

6) Coleman et al. (1994) Classification of prostanoid receptors: Properties, distribution and structure of the receptors and their subtypes Pharmacol.Rev. 46 205