Ferrostatin-1

Inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death [1]. Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices [1]. Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells [2]. Inhibits oxidative lipid damage and cell death in diverse disease models [3]. Prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species [4].

References:

1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death;  Cell, 149 1060

2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib;  Int. J. Cancer, 133 1732

3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models;  J. Am. Chem. Soc., 136 4551

4) Nowak et al. (2013), Protein kinase C-a interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells;  Am. J. Physiol. Renal. Physiol., 305 F764