Vinblastine Sulfate

Semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation1. Inhibits normal microtubule assembly and induces aberant tubulin polymerization [1]. Induces apoptosis in a variety of cell lines [2]. Inhibits autophagosome maturation [3]. Inhibits palmitoylation of tubulin [4].

References:

1) Hamel et al. (1996), Antimitotic natural products and their interactions with tubulin;  Med. Res. Rev., 16 207

2) Tsukidate et al. (1993), Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes;  Am. J. Pathol., 143 918

3) Satori et al. (2013), Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection; Anal. Chem., 85 11391

4) Caron and Herwood (2007), Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes; Chemotherapy, 53 51