Cytochalasin B

A cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization [1]. Inhibits cell division, migration and glucose transport [2]. Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells [3]. Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells [4]. CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication [5].

References:

1) PA Theadoropoulos et al. Biochem. Pharmacol. 1994 47:1875

2) RR Whitesell et al. Biochem. J. 2005 386:245

3) RJ Buldak et al. Eur. J. Histochem. 2014 58:2408

4) MO Gomzikova et al. Biomed. Res. Int. 2018 2018:7053623 (eCollection 2018)

5) MO Gomzikova et al. Oncotarget 2017 8:70496"5) Kalousec et al. (2007) Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes; Anticancer Drugs, 18 763