Streptozocin (Streptozotocin)

An N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes [1]. Alkylates DNA [2]. Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase [3]. Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition [4]. Is not a spontaneous NO donor [5].

References:

1) Szkudelski et al. (2001), The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.;  Physiol. Res., 50 537

2) Bennett & Pegg (1981), Alkylation of DNA in rat tissues following administration of streptozotocin;  Cancer Res., 41 2786

3) Konrad et al. (2001), The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase;  Biochem. J., 356 Pt 1 31

4) Gao et al. (2000), Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells;  Arch. Biochem. Biophys., 383 296

5) Kroncke & Kolb-Bachofen (1996), Streptozotocin is not a spontaneous NO donor.;  Free Radic. Res., 24 77