INK-128

A potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM [1]. Inhibits growth and proliferation of various breast cancer cell lines and human endothelial cells [2].

References:

1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55

2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673