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Neuromics
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Primary Antibody · Mouse IgG

c-Fos

Cited in 1 paper
Species
Human, Mouse, Rat
Applications
ICC, WB, IHC, IF

Published with this product (1)

Description

c-Fos is part of the Fos gene family; which consists of 4 members: FOS, FOSb, FOSL1 and FOSL2. Fos family genes are associated with JUN proteins and other basic leucine ipper (bZIP) domain proteins to create a variety of AP-1 (activator protein-1) complexes. c-Fos is considered to be an immediate-early gene because expression is normally low but rapidly and transiently in response to a wide array of stimuli including serum, growth factors, tumor promoters, cytokines, and UV radiation. It plays an important role in many cellular functions, and is over-expressed in variety of cancers.
Left: MO22162 staining (green) in HeLa cells, which were treated with serum-starvation for 36 hours, followed by 2 hours, 20% FBS stimulation (bottom panel), or PBS treatment (top panel). Middle: Mouse brain section labeled with MO22162 using a standard HRP-DAB staining technique Right: Mouse cortical section labeled with MO22162 (red) and our rabbit polyclonal anti Fox3/NeuN (RA22113) antibody (green) using immuno-fluorescent confocal-microscopy
Left: MO22162 staining (green) in HeLa cells, which were treated with serum-starvation for 36 hours, followed by 2 hours, 20% FBS stimulation (bottom panel), or PBS treatment (top panel). Middle: Mouse brain section labeled with MO22162 using a standard HRP-DAB staining technique Right: Mouse cortical section labeled with MO22162 (red) and our rabbit polyclonal anti Fox3/NeuN (RA22113) antibody (green) using immuno-fluorescent confocal-microscopy
Top panel: Western blot analysis of c-Fos expression in HeLa cells using MO22162. Lane 1: HeLa cells were serum-starved for 36 hours. 2: Serum-starved HeLa cells were stimulated with 20% FBS (fetal bovine serum) for 2 hours. MO22162 recognizes bands in the range of 50-65 kDa. Bottom panel: Blot was stripped and probed with our monoclonal antibody against GAPDH, MO25038 used as loading control.
Top panel: Western blot analysis of c-Fos expression in HeLa cells using MO22162. Lane 1: HeLa cells were serum-starved for 36 hours. 2: Serum-starved HeLa cells were stimulated with 20% FBS (fetal bovine serum) for 2 hours. MO22162 recognizes bands in the range of 50-65 kDa. Bottom panel: Blot was stripped and probed with our monoclonal antibody against GAPDH, MO25038 used as loading control.

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For research use only. Not for diagnostic or clinical use.