1-EBIO

1-EBIO has been shown to be an activator of Ca2+-activated K+ channels (SK) (1). It has also been shown to reverse ischemia-induced cognitive impairment (2) and display neuroprotective effects in ischemia-induced neuronal cell death (3). Research has also shown that 1-EBIO induces embryonic stem cell differentiation into cardiomyocytes (4). The molecule can also encourage production of superoxide and hydrogen peroxide in neutrophils leading to apoptosis (5).

References:

1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151

2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179

3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302

4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720

5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548