Description
Cholesterol metabolite. Endogenous agonist for nuclear receptor LXR [1]. Controls cellular cholesterol homeostasis [2]. Promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells [3]. Cell permeable.
References:
1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor igands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126
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For research use only. Not for diagnostic or clinical use.