JZL-184

JZL-184 has been shown to Inhibit MAG lipase (IC50=8 nM) selectively over FAAH. JZL-184 is cell permeable.

References:

1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects; Nat. Chem. Biol., 5 37

2) Pan et al. (2009), Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate (JZL 184) Enhances retrograde endocannabinoid signaling;  J. Pharmacol. Exp. Ther., 331 591

3) Kinsey et al. (2009), Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain; J. Pharmacol. Exp. Ther., 330 902