Doxycycline Monohydrate

A broad-spectrum tetracycline antibiotic [1]. Inhibits matrix metalloproteases [2]. Promotes wound repair by inhibiting collagen degradation in rat models [3]. Displays neuroprotective effects in neurodegenerative diseases [4]. Frequently used in doxycycline-controlled transcriptional activation systems for regulation of gene expression in cell culture and organisms [5,6].

References:

1) JL Riond and JE Riviere Vet. Hum. Toxicol. 1988 30:431

2) GN Smith et al. Arthritis Rheum.  1999 42:1140

3) S Lamparter et al. J. Lab. Clin. Med. 2002 139:295

4) FV Santa-Cecilia et al. Neurotox. Res. 2019 35:981

5) M Gossen et al. Science 1995 268:1766

6) Z Li et al. Proc. Natl. Acad. Sci. USA  2013 110:5004